This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq]

安諾倫(北京)生物科技有限公司是一家創辦于2015年的創新型高科技企業,公司由在國內科研試劑領域有著十幾年從業經驗的專業技術團隊和企業管理團隊組建而成,專門從事以抗體、蛋白、細胞、化學品為核心的試劑產品研發與銷售。擁有國內外數百家品牌試劑代理權,為眾多需求客戶及科研機構提供品質保障、價格合理和操作便捷的品牌試劑。
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